With Ibrahimovic nearly certain to be ruled out of this weekend's Premier League trip to Burnley, Europa League hero Marcus Rashford is set to deputise in his place and lead the United attack.
Sam Vokes and Scott Arfield remain doubts for the clash with Manchester United and will be a day of decision whether or not they will feature.
The loss of the latter could be pivotal as United have relied heavily on the 35-year-old, who has scored significantly more than anyone else in Mourinho's squad since he moved to Old Trafford in the summer. We don't have Jones or Smalling. Rooney's deflected shot from Ander Herrera's cutback was claimed by Heaton and Marouane Fellaini headed straight at the former United goalkeeper as a high-tempo start continued at a sunny Turf Moor.
When judged by a per-90 metric in the Premier League this season, Keane would appear to be a decent option for Jose Mourinho but not necessarily a major upgrade on the manager's current options.
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"They are a top side, you only have to look at the players they have, they are always going to be strong".
That victory is one of only two for Manchester United in their last 12 top-flight visits to Burnley (D5, L5).
The 19-year old did suffer a drought in the league for a long period but in recent weeks (3 goals in the last 3 games in all competitions) he has truly emerged into one of United's vital players and will be crucial in the run-in which includes a two-legged semi-final in the Europa League.
We all know about Burnley's home record, and this is a tough one for Manchester United straight after their Europa League tie against Anderlecht.
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His total is dwarfed by the overall haul Wayne Rooney has managed in his United career, though, and Ibrahimovic's absence may lead to the 31-year-old club captain having a more prominent role in the team's final few fixtures - something Dyche was quick to highlight when quizzed about his next opponents' injury issues. José Mourinho's side have earned 30 points from 14 games on the road, winning nine and losing just two.
Manchester United have the division's best points per game average in away matches (2.14).
United are facing another injury crisis - with three of their four regular center-backs unavailable for the trip to Burnley.
Keane has been an ever-present for the Clarets this season, starting all 33 of their Premier League outings.
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