Sunderland won away at Bournemouth in November so could do the double over another club for the first time in two years.
Sunderland's relegation from the Premier League could be confirmed if they lose to Bournemouth on Saturday.
Sunderland fans have seen their side win just three times in 17 attempts at the Stadium of Light in the Premier League this season (W3 D5 L9) - all three of those victories came within the space of 29 days (November 19 - December 17).
A reported target for next season for Eddie Howe is our the player we had on loan from West Ham for one season Jermain Defoe, he has scored 14 of Sunderlands 26 goals this season and will be a player for our defenders to contain.
GETTY Anthony Joshua and Wladimir Klitschko go head-to-head at Wembley on Saturday
"While there's a chance, I've got to keep going and we've all got to keep going".
And they could be without a further quartet, with Lee Cattermole, Darron Gibson, Jack Rodwell and Jason Denayer set to undergo late fitness tests.
He said: "Everyone is aware of the problems at the club".
"We have to try and get things right so the long-term project means there's a better future". They backed the team, home and away, in huge numbers throughout the season and it is fair to say this season they have once again been relentless in their support.
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I think you're not going to see him telegraphing how he's going to respond to any military or other situation going forward'. The North has said such launches are an act of deterrence against a potential invasion by the US or South Korea.
All in all I see this as a game that will go only one way and that is in the direction of the visitors.
Josh King is in good form at the moment and he could add to his goals tally on Saturday.
"It is about continuing our progression and momentum, but it will be a hard game, any away game in the Premier League is tough, so we will not be underestimating Sunderland".
"I think supporters are entitled to shout and vent their frustrations, and there's been frustrations here for four or five years, but the manager will always take the brunt of it".
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Alan Flake , a fetal surgeon at Children's Hospital of Philadelphia who led the study , said in a press statement . The research was published in the journal Nature Communications .
"It is an especially cruel blow for our supporters, who have shown tremendous faith in the club".
In 2014, the former Preston North End boss was appointed manager of La Liga side Real Socieded, following the sacking of Jagoba Arrasate, with the club sitting 15 in the table.
"We have come back a few times with some great fightbacks but weren't able to do it this season", the Republic of Ireland global said. The result moves Burnley to eight points above the relegation zone and should secure their top-flight status for another season.
Burnley x Manchester United- Game Preview
United are facing another injury crisis - with three of their four regular center-backs unavailable for the trip to Burnley . Keane has been an ever-present for the Clarets this season, starting all 33 of their Premier League outings.