At 6:15, he did it again.
United States of America swimmer clinches three golds in back-to-back events to take his personal haul to six.
Dressel has made plenty of statements at Budapest but the one that made Chalmers take notice was his scorching 47.17 second 100m freestyle winning time.
The 20-year-old Dressel underlined his credentials as the world's fastest starter in breathtaking fashion when he broke away on the butterfly leg to give the USA gold in the men's 4x100 meters medley relay.
Caeleb Dressel is on the verge of a super Saturday at the world championships after clocking the fastest times into both the men's 50m freestyle and 100m butterfly finals.
There is no love lost between the pair after King labeled Efimova a "drug cheat" at the Rio de Janeiro Olympics in Brazil previous year due to the Russian having served a 16-month ban for doping that ended in 2015.
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But the day belonged to Dressel, who now holds the undisputed title as the world's top sprinter.
His loss, coupled with Dressel's dominance here in Budapest - he has won six gold medals as of Saturday - may have set off alarm bells, but Eddie Reese, who trains Schooling at the University of Texas, said there is no need to press the panic button just yet. Great Britain ranks second with four.
Also at the event, 20-year-old American Caeleb Dressel became the first swimmer to win three gold medals in one night at the World Championships, with a victory in the 50-meter freestyle, the 100 butterfly and a world record showing in the 4×100 free relay.
Some 34 minutes later, he followed by swimming away with the 100 fly, a race that was never in doubt.
"I have 24 hours to my next swim, so I'll give myself 30 minutes tonight to let it sink in a bit and then it's time to refocus for the next event tomorrow", said Dressel.
Local favourite Kristof Milak, 17, took silver with a new world junior record time of 50.62sec.
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That did not stop him from eyeing two golds at this World Championships, as well as Michael Phelps' world record time of 49.82sec for the 100m fly set in the 2009 edition.
The Americans romped to another world record in the mixed free relay.
Asked about Dressel's time, he said: "It's fast". I got my a** kicked. "It was such a blast".
The 20-year-old swam the butterfly leg for the United States, with Matt Grevers (backstroke), Kevin Cordes (breaststroke) and Nathan Adrian (freestyle) the other contributors to a successful title defence.
Great Britain, led by breaststroke record-holder Adam Peaty, and a well-balanced Russian Federation appear to be the primary threats.
Kalisz, meanwhile, extended American rule of the 200-meter individual medley, rallying to claim his first major global championship.
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Chalmers, 18, admitted he would have to broaden his program with a bigger focus on the 200m freestyle if he were to have the endurance to compete with the breakout star of the world swimming championships at Budapest.