Second half goals from Victor Moses and Kelechi Iheanacho saw the Super Eagles securing their biggest win ever over Cameroon.
The Eagles are now unbeaten in 33 World Cup qualifying games.
The Indomitable Lions of Cameroon will host the Super Eagles in the second leg today, September 4 and the Indomitable Lions will want to overturn the first leg result where they were embarrassed in Uyo.
Mikel Obi and Victor Moses ran the Indomitable Lions ragged in Uyo.
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Moses scored once and helped set up two others as Nigeria hammered African champions Cameroon 4-0 in Uyo to keep up their 100% record in Group B.
"But we will now need to win our next three matches and expect Nigeria to lose their next three games to stand any chance".
"But we have to defend our honour".
"I watched the game against the Cameroonians on Friday and I am sure you have the ability to conquer them again in their own territory. If the players have the same attitude as me, we will fight to beat Nigeria". "So, I can say we have two good centre forwards who are ready to play on Monday".
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Coach Gernot Rohr must be reminded that in the qualifiers for the World Cup in Italy in I990, the Super Eagles needed to avoid defeat in the same stadium to qualify but succumbed to a 1-0 defeat, which automatically denied them the ticket.
Also, Udoh Emmanuel, Akwa Ibom state governor, had promised to reward them with $10,000 for each goal scored against the reigning African champions.
Burkina Faso top Group D with five points as they chase a maiden World Cup qualification, Senegal and South Africa have four and Cape Verde three.
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